Expression of cytokeratin 10, 16 and 17 as biomarkers differentiating odontogenic keratocysts from dentigerous cysts
김정민, 최소영, 김진수,
소속 상세정보
김정민 ( Kim Jung-Min ) - Kyungpook National University School of Dentistry Department of Oral and Maxillofacial Surgery
최소영 ( Choi So-Young ) - Kyungpook National University School of Dentistry Department of Oral and Maxillofacial Surgery
김진수 ( Kim Chin-Soo ) - Kyungpook National University School of Dentistry Department of Oral and Maxillofacial Surgery
KMID : 0355620120380020078
Abstract
Objectives: Odontogenic keratocysts (OKCs) have a tendency to recur and possess an aggressive nature. the aim of the present study was to evaluate cytokeratin (CK) expression patterns as a method for the differentiation between dentigerous cysts (DCs) and OKCs, as their histomorphologic appearance are often indistinguishable. Materials and Methods: Formalin-fixed, paraffin-embedded tissue sections of 43 OKCs and 38 DCs were immunohistochemically analyzed with
i-solution in a quantitative manner in order to evaluate the immunoreactivity of CK 10, 16 and 17. Results: CK 10 expression was evident in 79.1% of OKCs but found in only 18.4% of DCs (P <0.05), and CK 10 expression was observed to occur more frequently in OKCs (mean 25.45%) than in DCs (2.19%) (P<0.05). The expression of CK 16 was evident in 79.1% of OKCs but found in only 7.9% of the DCs (P <0.05) and CK 16 expression was observed to occur more frequently in OKCs (mean 4.33%) than in the DCs (0.61%) (P <0.05). The expression of CK 17 was evident in 88.4% of OKCs but seen in only 15.7% of the DCs (P <0.05) and CK 17 expression was observed to occur more frequently in OKCs (mean 31.11%) than in the DCs (2.37%) (P <0.05). Conclusion: The immunohistochemical detection of CK 10, 16 and 17 can be utilized as a valuable biomarker for use in distinguishing between OKCs and DCs, which have clinically significant differential diagnoses.
키워드
Cytokeratin 10; 16 and 17; Odontogenic keratocyst; Dentigerous cyst
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